Research themes

  • Cardiac metabolism
  • Circadian biology
  • Women’s heart health

Research interests

  • Studying how circadian misalignment (shift work) adversely affects cardiovascular health of the mother and fetus into adolescence
  • Uncover the circadian factors and pathways by which circadian misalignment leads to cardiometabolic dysfunction and contribute to development of heart failure
  • Studying the genes and networks that are associated with both circadian rhythms and metabolic function toward developing innovative therapeutic strategies to treat cardiometabolic dysfunction

Research affiliations

  • Principal investigator, Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre

Research summary

Dr. Rabinovich-Nikitin’s research program focuses on understanding sex-dependent influences that link circadian biology and cardiometabolic dysfunction in heart failure. Studies are directed toward understanding the molecular signaling pathways that impact cardiac metabolism and the environmental influences imposed by alterations in the light/dark cycle.

In addition, Dr. Rabinovich-Nikitin’s research program focuses on pregnancy complications, and how disrupting light/dark cycles during pregnancy mutually affect the mother and the fetus. The long-term goal of this research is directed toward developing new therapeutic strategies that will mitigate cardiometabolic dysfunction and heart failure, as well reduce the increased risk for cardiovascular disease from pregnancy complications.

Biography

Dr. Rabinovich-Nikitin received her PhD from Tel-Aviv University, followed by a postdoctoral training at the University of Manitoba, where she received a fellowship from the Canadian Institute of Health Research (CIHR).

Dr. Rabinovich-Nikitin focuses her research program on women’s heart health, with the goal to advance knowledge and education toward improved diagnosis, treatment and quality of life of women with cardiac disease. She is highly involved in advocacy programs as well as knowledge translation activities to increase knowledge and awareness on Women’s Heart Health.

Dr. Rabinovich-Nikitin has a track record of publishing in high quality, peer-reviewed journals, including Circulation, Journal of Clinical Investigations, Circulation Research, Autophagy, Nature Communication, Cardiovascular Research and others.

She co-editing a book on the Biology of women’s heart health and a special issue on cardiac growth control and heart cell death in the journal Cells.

She also serves on many journal editorial boards, including Circulation Research and Molecular and Cellular Biochemistry, as well as Associate Editor in Canadian Journal of Physiology and Pathophysiology.

Education

Post-doctoral fellowship, department of physiology and pathophysiology, University of Manitoba

PhD in biotechnology, department of molecular microbiology and biotechnology, Tel Aviv University

Master of science in biotechnology, department of molecular microbiology and biotechnology, Tel Aviv University

Bachelor of science in biology, Tel Aviv University

Awards

2024:

  • Women in Health Sciences Award, University of Manitoba

2023:

  • Outstanding Early Career Investigator Award, NIH Progenitor Cell Translational Consortium
  • Buddha Dawn Early Career Award, International Academy of Cardiovascular Sciences (IACS), North American Section

2022:

  • International Society for Heart Research, Young Investigator Best Research Presentation Award
  • Louis N. and Arnold M. Katz Basic Science Research Prize for Early Career Investigators, American Heart Association (AHA)

2021:

  • International Academy of Cardiovascular Sciences, Dr. Roberto Bolli Young Investigator Competition Award

2020:

  • Martha Donovan Women’s Leadership Development Award, The Winnipeg Foundation, University of Manitoba
  • International Society for Heart Research North American Section, Young Investigator Competition Award Finalist
  • American Heart Association, Paul Dudley White International Scholar

2017:

  • Arnold Naimark Young Investigator Award, 19th annual Institute of Cardiovascular Sciences Awards Day

2017-2021:

  • Canadian Institute of Health Research, Postdoctoral Fellowship Award

Contact us

Physiology and Pathophysiology
432 Basic Medical Sciences Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, MB R3E 0J9 Canada

204-789-3696
204-789-3934